It works as an allosteric inhibitor or an activator or in combination. This site controls various metabolic pathways and allows them to take place in a step-by-step manner.Įffector molecule: A ligand that alters the dynamics of protein functions. There is no direct relation with the protein’s active site but an allosteric site alters the reaction taking place in the active site. Regulation takes place either through feedback control loop (downstream products) or feed-forward loop (upstream substrates).Īctive site: Substrate molecules bind and catalyze a reaction.Īllosteric site: An effector molecule will bind at this site. These are very important for cell signaling and to increase the ability and tolerance of the cells to various enzymatic activities. The term ‘ allosteric’ refers to biochemical regulatory processes that involve a change in the conformational structure and dynamics of a protein molecule when it attaches to another molecule at a site apart from its regular active site. The various terms associated with allosteric regulation and activators are:Įnzymes: Protein molecules and biological catalysts that activate metabolic reactions. Terms Associated with Allosteric ActivatorsĪllosteric activators are part of regulatory processes of enzyme activity. The active and the allosteric regulatory sites of a protein molecule physically differ. Allosteric regulation regulates by activating or inhibiting the protein activities through the effector molecules in the form of allosteric activators or inhibitors at a site (allosteric) other than the enzyme’s active site. In Greek, ‘allos’ means ‘other’, and ‘steros’ means ‘solid’. The biological activities involved with proteins like gene expression, protein translation, and degradation are regulated through allosteric regulations.
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